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Massachusetts Technology Portal

A unified search engine serving as a one-stop shop for technologies available for license from Massachusetts research institutions.
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Search results:   273 matches found Sort by:      

1. Overexpression of Mammalian and Viral Proteins
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Research Tools   |  Drug Discovery Tools
Inventor:  Haas, Juergen G.; Park, Eun-Chung; Seed, Brian S.
Abstract:

The invention features a synthetic gene encoding a protein normally expressed in mammalian cells wher ...

2. Nitric Oxide and Nitric Oxide Synthase Affect Lymphatic Function
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Methods
Inventor:  Fukumura, Dai; Hagendoorn, Jeroen; Jain, Rakesh K.; Padera, Tim
Background:

The lymphatic network plays a physiologically crucial, dual role in both immune function and the ma ...

3. Diagnostic and Therapeutic Alkylendeiamine Compounds and Process
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Methods   |  Therapeutics - Drugs
Inventor:  Choi, Sung-Woon; Elmaleh, David R.; Hanson, Robert
Diamine compounds useful for treating neurodegenerated diseases characterized by the lack of dopamine neurons activity o ...

4. Compositions and Methods that Enhance RNA Interference
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Research Tools   |  Therapeutics - Methods   |  Drug Discovery Tools   |  Therapeutics - Methods
Inventor:  Kennedy, Scott; Ruvkun, Gary B.; Wang, Duo
Background:

Exposure of a cell or organism to double stranded RNA (dsRNA) can cause the degradation of mRNA mol ...

5. Co-Cultivation of Cells in a Micropatterned Configuration
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Research Tools   |  Research Tools   |  Research Tools
Inventor:  Bhatia, Sangeeta; Toner, Mehmet; Yarmush, Martin L.
Background:

Co-cultivation of hepatocytes with another cell type has been recognized to prolong cell survival r ...

6. Small Molecule Protection of the Ovary from Radiation-Induced Damage
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Methods   |  Vaccines   |  Therapeutics - Drugs
Inventor:  Kolesnick, Richard N; Tilly, Jonathan L.
Published Application US20030157086A1: Protection of the female reproductive system from natural and artificial insults ...

7. Delivery of Therapeutic Biologicals from Implantable Tissue Matrices
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Drug Delivery   |  Therapeutics - Drugs   |  Drug Delivery
Inventor:  Detmar, Michael J; Donahoe, Patricia K.; Maclaughlin, David T.; Stephen, Antonio; Streit, Michael R W; Vacanti, Joseph P.; Velmahos, George
Background:

Protein therapeutics, as effective agents for treatment of cancer, require large quantities of the ...

8. 3D-Plexicube Assay to Study the Emergence of Micro-Tumor Systems
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Research Tools   |  Drug Discovery Tools
Inventor:  Chiocca, Ennio Antonio; Deisboeck, Thomas; Wright, Iain
Background:

This invention is a growth support apparatus for analyzing three-dimensional micro-tumor growth in ...

9. Polynucleotide and Polypeptide Fat Metabolism Regulators in the Tub Pathway and Related Pathways and Uses Thereof
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Methods
Inventor:  Mak, Ho Yi; Ruvkun, Gary B.
Applications:

- Drug targets for prevention and treatment of obesity and obesity-related diseases
- Metho ...

10. Methods & Compositions for Treating Vascular Stenosis
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Methods   |  Therapeutics - Drugs
Inventor:  Bunting, Stuart; Garabedian, Harry D.; Gold, Herman K; Leinbach, Robert L; Schwall, Ralph H.
Methods for treating vascular stenosis using hepatocyte growth factor ("HGF") are provided. In the methods, HGF can be a ...

11. Enhanced Detection and Therapy of Inflamed Tissues Using Immune Modulation
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Methods
Inventor:  Gelfand, Jeffrey A; Hamblin, Michael R.; Migrino, Raymond Q.; Tawakol, Ahmed A
SUMMARY

Background:
Current therapies treat the result of inflammation, not the cause, and thus suffer fro ...

12. Application and modification of histological stains as magnetic resonance imaging contrast agents
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Diagnostics/Biomarkers   |  Medical Imaging
Inventor:  Blackwell, Megan L; Farrar, Christian T; Rosen, Bruce R.
BACKGROUND

Higher magnetic field strengths and more powerful gradient systems developed in recent years have r ...

13. The ROC Method for early detection of Ovarian Cancer
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Diagnostics/Biomarkers
Inventor:  Jacobs, Ian; Knapp, Robert C.; Skates, Steven J.
A method of assessing risk of an individual for a disease is disclosed. A level of a marker for the disease is detected, ...

14. Photodynamic Ablation of Cardiac Tissue
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Methods   |  Therapeutics - Drugs
Inventor:  Milan, David J; Reddy, Vivek; Ruskin, Jeremy N
Background:

Cardiac Arrhythmias are medical ailments that may affect the performance of the heart. In subjects ...

15. Assay for Detection of QT Prolongation by Pharmacological Agents in Zebrafish
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Research Tools   |  Drug Discovery Tools
Inventor:  Burns, C. Geoffrey; MacRae, Calum; Milan, David J; Peterson, Randall; Peterson, Travis
Zebrafish assay for Predicting Cardiotoxicity

BACKGROUND OF INVENTION

Side effects, e.g., cardiovasc ...

16. Treatment of Ischemic Cardiac Malfunction
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Methods   |  Therapeutics - Methods   |  Therapeutics - Drugs
Inventor:  Haupert, Garner Tripp
Abstract:

The present invention is based on the unexpected discoveries that hypothalamic inhibitory factor (HIF ...

17. Protection of Skin During PDT
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices
Inventor:  Anderson, Richard Rox; Battle, Eliot; Joe, Edwin K; Ortel, Bernhard Johannes
Background:

The major disease of skin associated with sebaceous follicles is acne vulgaris. This is also the m ...

18. Single Dose Syringe Driver
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices   |  Drug Delivery
Inventor:  Sims, Nathaniel M.; Wollowitz, Michael
Background:

A recent trend in hospital pharmacies has been the increasing use of syringes for storing and deliv ...

19. Desensitization of the G-Coupled Receptor, GPR54, for Therapeutic PUrposes by Continuous Infusion of metastin 45-54 and/or its Analogues
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Methods
Inventor:  Crowley, William F. Jr.; Cuny, Gregory; Glicksman, Marcie; Kaiser, Ursula B.; Kuohong, Wendy; Plant, Tony; Seminara, Stephanie; Stein, Ross L.
Published in Endocrinology 147(5): 2122-2126, 2006

Contiuous Human Metastin 45-54 Infusion desensitizes G Prote ...

20. Topical ALA-PDT for Treatment of Acne
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Methods
Inventor:  Anderson, Richard Rox
Background:

The major disease of skin associated with sebaceous follicles is acne vulgaris. This is also the m ...

21. Transmit-Receive Array for High FIeld MRI
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Imaging   |  Medical Devices
Inventor:  Wald, Lawrence L; Wiggins, Graham Charles
BACKGROUND OF THE INVENTION

When a substance such as human tissue is subjected to a uniform magnetic field (pol ...

22. Gene-based Clinical Scoring System
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices   |  Software/Algorithms
Inventor:  Elson, Constance M.; Hayden, Douglas; Schoenfeld, David A.; Tompkins, Ronald G; Warren, Shaw
Brief Description of Technology:

A single score representing chanes in gene expression in peripheral blood leuk ...

23. Peptide-Based Delivery Module Across the Blood Brain Barrier
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Diagnostics/Biomarkers   |  Drug Discovery Tools   |  Diagnostics/Biomarkers
Inventor:  Moore, Anna V; Pham, Wellington
The improved bioavailability of drugs or imaging probes in the brain for the treatment/detection of the central nervous ...

24. Microchannel Device to Separate (Segregate) Blood Cells
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices   |  Diagnostics/Biomarkers
Inventor:  Bitensky, Mark W; Munn, Lance L.; Shevkoplyas, Sergei S.; Sun, Chenhai; Yoshida, Tatsuro
Microchannel Device to Separate (Segregate) Blood Cells

Invention: A device to separate particles of different ...

25. Specific Aryl Bidentate Isonitriles and Their Uses
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Diagnostics/Biomarkers   |  Medical Imaging
Inventor:  Das, Bhaskar; Elmaleh, David R.; Fischman, Alan; Shoup, Timothy M.
"Specific Aryl Bidentate Isonitriles and Their Uses"
(MGH - 3133)

INVENTOR
Elmaleh, David; Shoup, Tim ...

26. A Non-Invasive Method to Detect Gene Delivered into Brain Cells of Live Animals
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Imaging   |  Drug Delivery
Inventor:  Kim, Young Ro; Liu, Christina H.; Liu, Philip K.; Rosen, Bruce R.
BACKGROUND
A number of different approaches to imaging cells have been investigated using either optical, e.g., usi ...

27. Photosensitizer Conjugates for Targeting Intracellular Pathogens
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Methods
Inventor:  Gross, Jerome; Hasan, Tayyaba; Nau, Gerard J.
Background:

Over one-third of the world's population is infected with Mycobacterium, the causative agent for tu ...

28. Photoimmunotargeting Using Conjugates Prepared from Light Activatable Molecules
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Methods
Inventor:  Hasan, Tayyaba
Invention Summary: Indirectly linked photosensitizer immunoconjugate (PIC) compositions for use in photodynamic therape ...

29. Defatting of Organs for Transplantation
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Drugs   |  Therapeutics - Drugs
Inventor:  Berthiaume, Francois; Mokuno, Yasuji; Yarmush, Martin L.
Background:

The major impediment limiting clinical transplantation of organs is the persistent shortage. Moreo ...

30. Portable Negative Pressure Ventilation System
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices   |  Medical Devices   |  Therapeutics - Drugs
Inventor:  Jiang, Yandong; Kacmarek, Robert M.; Zapol, Warren M.
INTRODUCTION
Each year millions of patients in the U.S. require oxygen therapy whether they are at the hospital, at ...

31. Delivery of Inhaled Dry Powder Medications to Patients with Lung Insufficiency
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices   |  Drug Delivery
Inventor:  Dalbec, Ronald; Johnson, Douglas C.
Application:
Until this invention, there has been no method to deliver dry powder medications to patients of the fo ...

32. Smallpox Innoculation Training System
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices
Inventor:  Bardsley, Ryan; Dawson, Steven L.; Waddington, Robert
Applications:

The goal of this system is to quickly and accurately familiarize a user with the complete smallpo ...

33. Plasma-supplementation for Improved Hepatocyte Survival in Liver-assist Devices
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:  
Inventor:  Berthiaume, Francois; Toner, Mehmet; Washizu, Junji; Yarmush, Martin L.
Background:

Bioartificial liver (BAL) assist systems are a promising avenue for the treatment of liver failure ...

34. Use of a Non-Mammalian DNA Virus to Express an Exogenus Gene in A Mammalian Cell
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Research Tools   |  Drug Discovery Tools
Inventor:  Boyce, Frederick M.
Background:

Currently, different methods allow expression of an exogenous gene in a mammalian cell. Among these ...

35. Urinary proteomics for predicting pregnancy complications
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Diagnostics/Biomarkers
Inventor:  Knickerbocker, Tanya Lynn; MacBeath, Gavin; Thadhani, Ravi I.; Wolf, Myles
Published application WO05017192A3: SCREENING FOR GESTATIONAL DISORDERS
The invention is based, in part, on the dis ...

36. Integrated Photodynamic and Differentation Therapy
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Methods
Inventor:  Hasan, Tayyaba; Maytin, Edward V; Ortel, Bernhard Johannes
Background:

Topical 5-aminolaevulinic acid (ALA) photodynamic therapy (PDT) is an approved method for the treat ...

37. X-Inactivation Markers as a Tool to Determine the Pluripotency and Differentiation Potential of Human Embryonic Stem Cell (hESC) Lines
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Research Tools   |  Drug Discovery Tools
Inventor:  Lee, Jeannie T
Background:

Pluripotency of human embryonic stem cells ("HESC") is critical to the usefulness of existing cell ...

38. Anthrax Spore Proteins with Potential for Development of More Effecacious Anthrax Vaccines, Drugse and Spore-Activation Strategies
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Vaccines
Inventor:  Calderwood, Stephen B.; John, Manohar; Kudva, Indira
Background:

When anthrax exposure/infection is diagnosed early, there are therapeutic options including the adm ...

39. High Affinity Indocyanine Flurochrome Binding Peptides
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Imaging
Inventor:  Kelly, Kimberly A.; Weissleder, Ralph
Case Manager: Daniel Castro, M.B.A.

Title: High Affinity Indocyanine Fluorochrome Binding Peptides (MGH 3393) ...

40. Kidney precursor Stem Cells Flk1+Sca1+
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Methods   |  Therapeutics - Drugs
Inventor:  Arnaout, Amin M; Linde, Peter G.; Morales, Alejandro; Von Visger, Jon
Background
Acute and chronic kidney diseases are common clinical problems with increasing incidence, serious consequ ...

41. Replacement Heart Valve Devices
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices
Inventor:  White, Jennifer K.
Background:

Hundreds of thousands of patients in the U.S alone could potentially benefit from heart valve recon ...

42. Netrin Compositions and Methods of Using the Same to Treat Inflammation
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Research Tools   |  Therapeutics - Methods   |  Research Tools   |  Therapeutics - Drugs
Inventor:  Kinane, Thomas B.; Komatsuzaki, Katsumi; Ly, Ngoc
Background:

Inflammatory reactions can provide an essential defense to infection and injury. At the same time, ...

43. Detection and Therapy of Vulnerable Plaque with Photodynamic Compounds
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Diagnostics/Biomarkers   |  Medical Devices
Inventor:  Anderson, Richard Rox; Daghighian, Farhad; Elmaleh, David R.; Fischman, Alan; Gewirtz, Henry; Hamblin, Michael R.; Hasan, Tayyaba; Muller, James E.; Tawakol, Ahmed A
Background:

In the U.S. alone, roughly 2600 people die each day as a result of cardiovascular disease. Of the ...

44. Leukocyte-Specific Protein & Gene and Methods of Use Thereof
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Methods   |  Therapeutics - Drugs   |  Diagnostics/Biomarkers
Inventor:  Bloch, Donald B.; Bloch, Kenneth D.
Summary:

The present invention is directed to a leukocyte-specific gene Sp140 and its associated protein. Since ...

45. Process for Large-Scale Isolation and Purification of Hypothalamic Inhibitory Fa
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Methods
Inventor:  Gallagher, Rex; Haupert, Garner Tripp
BACKGROUND OF THE INVENTION
Hypothalamic inhibitory factor (HIF), an isomer of ouabain, is a physiologic inhibi ...

46. Method for Restoring Vision in Persons Due to Photoreceptor Cell Degeneration
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Methods
Inventor:  Masland, Richard H.
Background:

Most people become blind because of degeneration of their photoreceptor cells. The most common con ...

47. Brillouin Optical Microscopy
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices
Inventor:  Yun, Seok-Hyun Andy
Background:

Brillouin Optical Microscopy is a new microscopy apparatus and method, based on light scattering in ...

48. Biological Artificial Liver Loop and Dialysis (BALLAD) Recirculation System
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices
Inventor:  Linde, Peter G.; Williams, Winfred W
TECHNICAL FIELD
This invention relates to the field of extracorporeal blood treatment systems, such as bioartif ...

49. Catheter and method for Hybrid Fluroescence and Optical Coherence Tomography Imaging
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices   |  Medical Imaging
Inventor:  Jaffer, Farouc; Ntziachristos, Vasilis
INVENTION
The present invention relates to medical imaging and apparatus and process for generating fluorescence ima ...

50. EVE
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Software/Algorithms
Inventor:  Bardsley, Ryan Scott; Cotin, Stephane; Dawson, Steven L.; Duriez, Christian M.; Lenoir, Julien R.; Neumann, Paul Francis; Pegoraro, Vincent; Wu, Xunlei
In general, the present invention provides methods and apparatus for real-time computer-based simulation of vascular or ...

51. Compositions Comprising Grim-19 and Methods of Use Thereof For the Treatment of Intracellular Pathogens
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Diagnostics/Biomarkers   |  Therapeutics - Drugs
Inventor:  Podolsky, Daniel K.
Background:

Enteric diseases such as Crohn's disease and inflammatory bowel disease (IBD) are characterized by ...

52. Method and Apparatus for Detection and Treatment of Autonomic System Imbalance
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices
Inventor:  Armoundas, Antonis
Inventors:

Armoundas, Antonis A.; Chon, Ki H.

Background:

Sudden Cardiac Death (SCD) is major ...

53. Combination Antiangionenic Therapy For Cancer
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Methods   |  Therapeutics - Methods   |  Therapeutics - Methods
Inventor:  Chung, Daniel C.; Mizukami, Yasuke
Background:

Currently, one of the only FDA approved agents for antiangiogenic therapy is a neutralizing antibod ...

54. Intravascular Radiofrequency Coil for Vessel Wall NMR Imaging and Spectroscopy
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Diagnostics/Biomarkers   |  Medical Imaging
Inventor:  Ackerman, Jerome L.; Wedeen, Van J.
In one aspect, the present invention provides a coil for transmitting and detecting magnetic excitations. A coil of the ...

55. Anesthesia Billing and Data Analysis
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Research Tools   |  Drug Discovery Tools   |  Research Tools
Inventor:  Anupama, Shaji; Arslanian-Moraites, Lynn; Driscoll, William; Hannenberg, Leo; Marcus, Daniel; Nickell, Heather; Spring, Stephen; Walsh, John
Background:
Used by anesthesiologists, the Metavision Information Management System (iMDSoft) is a suite of software ...

56. Diffusion Encoding with 2D Gradient Trajectories Yields Natural Contrast for 3D Fiber Orientation
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Imaging
Inventor:  Wedeen, Van J.
BACKGROUND OF THE INVENTION

The field of the invention is nuclear magnetic resonance imaging (MRI) methods and ...

57. HCV Epitopes
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Methods   |  Therapeutics - Drugs
Inventor:  Lauer, Georg; Ouchi, Kei; Walker, Bruce D.
Background:

The invention contains claims directed to immunogenic compositions containing Hepatitis C Virus (HC ...

58. A Novel Acyltransferase for the Zebrafish Cloche Locus
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Research Tools   |  Drug Discovery Tools
Inventor:  Fishman, Mark C.; Xiong, Jing-Wei
Background:

Cardiovascular and ischemia related diseases remain a major cause of mortality worldwide, despite r ...

59. Devices and Methods for Percutaneous Mitral Valve Repair
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices
Inventor:  Grimes, Randall Y.
Devices and methods are provided for diagnosing and repairing mitral valve defects such as mitral valve regurgitation. < ...

60. Surgical training system for laparoscopic procedures
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices
Inventor:  Bardsley, Ryan Scott; Cotin, Stephane; Dawson, Steven L.; Neumann, Paul Francis; Ottensmeyer, Mark; Russell, Michael; Stylopoulos, Nicholas
The present invention provides a surgical training system having an instrument tracking module for tracking the position ...

61. Binding of Retinoids to M6P/IGF-11 Receptor
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Drug Discovery Tools   |  Research Tools
Inventor:  Kang, Jing X; Leaf, Alexander
Binding of Retinoids to M6P/IGF-11 Receptor

Disclosed are methods for inhibiting proliferation of a cell or ind ...

62. The Use of a Plant Extract and Related Compounds from Plants in Diagnosis and Treatment of Obesity, Diabetes, and Atherosclerosis
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Methods
Inventor:  Bao, Ju; Brooks, Peter C.; Chang, Young Tae; Huang, Paul L.; Huang, Philip Lin; Lee, Jae Wook; Lee-Huang, Sylvia; Liebes, Leonard; Sun, Yongtao; Zhang, Dawei; Zhang, John Z. H.
The Use of a Plant Extract and Related Compounds from Plants in Diagnosis and Treatment of Obesity, Diabetes, and Athero ...

63. MR Detection of Gene Activator Proteins in Live Animals
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Imaging   |  Diagnostics/Biomarkers
Inventor:  Liu, Chang-Ming; Liu, Christina H.; Liu, Philip K.
A number of different approaches to imaging cells have been investigated using either optical, e.g., using green fluores ...

64. Folylpolyglutamate Synthetase Gene Transfer To Enhance Antifolate Sensitivity Dr
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Methods
Inventor:  Aghi, Manish; Breakefield, Xandra O.; Kramm, Christof
Background:

The widely used antifolate drugs are also toxic to normal tissues. Their effectiveness as anti-canc ...

65. Percutaneous Stent Graft For Vascular Bypass
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices   |  Therapeutics - Methods   |  Medical Devices
Inventor:  Fan, Chieh-Min
A prosthetic vessel graft assembly has a tube of synthetic graft material surrounding a stent at its distal end, togethe ...

66. Spectrally Encoded Miniature Imaging Probe
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices   |  Diagnostics/Biomarkers
Inventor:  Bouma, Brett E.; Rosen, Jonathan J; Shishkov, Milen; Tearney, Guillermo J.
Background:

Widespread clinical use of laparoscopy and endoscopy have decreased patient morbidity and significa ...

67. Systems and Methods for Multipspectral Imaging
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices   |  Medical Imaging
Inventor:  Themelis, George
Summary: The present invention describes a technology and a method for multispectral imaging. The technology enables sim ...

68. Methods for Screening HIF Like Ouabain-Resistant Na-K-ATPase
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Research Tools   |  Drug Discovery Tools
Inventor:  Haupert, Garner Tripp
BACKGROUND OF THE INVENTION

Na+-K+-ATPASE is a plasma membrane-associated enzyme. Activity of the Na+-K+-A ...

69. NMR-Based Method of Measuring Ions Using Magnetic Particles
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Diagnostics/Biomarkers
Inventor:  Josephson, Lee; Taktak, Sonia; Weissleder, Ralph
Background:
NMR-based methods using surface modified magnetic particles have recently emerged as a powerful tool t ...

70. Therapeutic and Diagnostic Tools for Impaired Glucose Tolerance Conditions
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Methods   |  Therapeutics - Drugs
Inventor:  Kimura, Koutarou; Koweek, Allison; Morris, Jason; Ogg, Scott; Paradis, Suzanne; Patterson, Garth I.; Ruvkun, Gary B.; Tissenbaum, Heidi
Background:

Diabetes is a major glucose intolerance disease affecting over 16 million individuals in the United ...

71. Protein repellent/Fugetaxin for T-Cells in Conditioned Medium from EL-4 Cells
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Drug Discovery Tools   |  Drug Discovery Tools   |  Drug Discovery Tools   |  Therapeutics - Methods
Inventor:  Doughty, Dahlia; Poznansky, Mark C.
Summary
Heat Shock Protein - HSP90 was identified as a significant fugetactic (repellant) agent in EL-4 (murine thyo ...

72. Epitopes of Human Immunodeficiency Virus-1
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Vaccines   |  Diagnostics/Biomarkers
Inventor:  Addo, Marilyn; Altfeld, Marcus; Walker, Bruce D.; Yu, Xu
Background:

A critical factor in the treatment and prevention of certain infectious diseases, including HIV-1, ...

73. System and Methods of Light-Scattering Based In Vivo Flow Cytometry
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Imaging   |  Diagnostics/Biomarkers
Inventor:  Georgakoudi, Irene; Lin, Charles P.
Background:

Current methods for detecting and quantifying various types of cells circulating within a subject's ...

74. Purposeful Movement of Human Migratory Cells Away From an Agent Source
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Methods   |  Therapeutics - Drugs
Inventor:  Luster, Andrew D.; Potts, John T.; Poznansky, Mark C.; Scadden, David T.; Vianello, Fabrizio
SUMMARY:
The invention covers isolation and identification of eukaryotic migratory-cell repellant substances or "fu ...

75. Interference with Alphavbeta3 Integrin for the Treatment of Proteinuric Kidney Diseases
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Methods
Inventor:  Reiser, Jochen
N/A

SUMMARY
This invention provides a method for treating disorders characterized by proteinuria by admin ...

76. Microfabricated Membranes for Tissue Engineering
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Methods   |  Medical Devices   |  Therapeutics - Methods
Inventor:  Morgan, Jeffrey A; Pins, George
Background:

Synthetic membranes become increasingly important in the emerging field of tissue engineering. The ...

77. Non-Defective Epstein-Barr Viral Vector
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Methods
Inventor:  Chiocca, Ennio Antonio; Hochberg, Fred H.; Jiang, Xiaogun
Background:

One of the main objectives of gene therapy is to achieve stable, efficient, and persistent genetic ...

78. An Algorithm for Computing and Analyzing Heart Rate Variability
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Software/Algorithms   |  Medical Devices
Inventor:  Barbieri, Riccardo; Brown, Emery Neal; Matten, Eric C.
Background
Heart rate variability is an important quantitative marker of cardiovascular regulation by the autonomic ...

79. Variable Depth Photocoagulator/Heater
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices
Inventor:  Anderson, Richard Rox; Domankevitz, Yacov
U.S. Patent No. 6,529,543
Abstract: The invention features systems and tools for controlling the optical penetratio ...

80. Method and Device for Determining Cardiac Output with CO2 Partial Re-Breathing
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices
Inventor:  Jiang, Yandong; Kacmarek, Robert M.; Liang, Yafen
Case Manager: Daniel Castro, M.B.A.

Title: "Method and Device for Determining Cardiac Output with CO2 Partial ...

81. PercDepthTM -- Depth Gauge for Percutaneus Bone Screws
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices
Inventor:  Bhattacharyya, Timothy; Wixted, John J.
Background:

Bone screws are generally used in surgery to realign and set broken bones. Accurate measurement of ...

82. Triple Hybrid Amplicon Vector Systems to Generate Retroviral Packaging Lines
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Research Tools   |  Therapeutics - Methods   |  Drug Discovery Tools
Inventor:  Breakefield, Xandra O.; Esteves, Miguel S; Saeki, Yoshinaga
Background:

The success of gene therapy largely relies on efficient delivery of a gene to its target cells. Ret ...

83. Measuring bone mineral characteristics using differential cross polarization and adiabatic demagnetization in a rotating frame with magnetic resonance
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices   |  Diagnostics/Biomarkers
Inventor:  Ackerman, Jerome L.; Ramanathan, Chandrasek
In one general aspect, the invention features a magnetic resonance method that includes producing a state of dipolar ord ...

84. Biomarkers of Myocardial Ischemia
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Diagnostics/Biomarkers
Inventor:  Fifer, Michael A.; Gerszten, Robert E; Sabatine, Marc
MGH 2697: Biomarkers of Myocardial Ischemia

Inventors: Robert E Gerszten, Marc Sabatine, Michael F ...

85. Methods and Devices for Cell Culturing and Organ Assist Systems
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices
Inventor:  Balis, Ulysses J; Tilles, Arno A.; Toner, Mehmet; Yarmush, Martin L.
Background:

Cirrhosis is the sixth leading cause of death in the U.S. and ranks eighth in economic cost among m ...

86. MRI of Cross-Fiber Diffusion
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Software/Algorithms   |  Medical Imaging
Inventor:  Wedeen, Van J.
Background:

In the past decade, magnetic resonance imaging (MRI) methods have been developed that by mapping th ...

87. Wide-Field High-Resolution Optical Imaging
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices
Inventor:  Anderson, Richard Rox; Webb, Robert H.; Yaroslavsky, Anna N.
Background:

Confocal microscopy (CM) is a technique where the specimen is pointwise illuminated by a focused be ...

88. Blocking Anthrax Polypeptide binding to Receptors
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Diagnostics/Biomarkers   |  Therapeutics - Drugs
Inventor:  Arnaout, Amin M; Xiong, Jiang Ping
Blocking Receptor Binding to Anthrax Polypeptides

Anthrax infection remains a threat to public health. Althou ...

89. Activation-Dependent Protein Expressed on the Surface of Activated Platelets and Antibodies Thereto
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Methods
Inventor:  Matsueda, Gary R; Reed, Guy L.
Abstract:

The present invention provides a thrombin-activated platelet protein (TAPP). The protein is selective ...

90. Fluorescence Detection of Cell Proliferation
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Diagnostics/Biomarkers
Inventor:  Anderson, Richard Rox; Gillies, Robert; Kollias, Nikoforos
U.S. Patent No. 5,456,260
Abstract: The method of the present invention is directed at detecting non-invasively and ...

91. Enhanced Packaging of Herpes Virus Amplicons and Generation of Recombinant Virus
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Research Tools   |  Drug Discovery Tools
Inventor:  Ackermann, Mathias; Adema, Gosse; Breakefield, Xandra O.; Chiocca, Ennio Antonio; Fraefel, Cornel; Saeki, Yoshinaga; Shortman, Ken; Suter, Mark; Tobler, Kurt
Background:

Most viral vector systems currently used for gene therapy require the use of a helper virus for pac ...

92. Mechanical Separations of Blood
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices   |  Diagnostics/Biomarkers
Inventor:  Burger, Douglas; Faustman, Denise L.
Background:

There are many clinical settings where tests on white blood cells (WBCs) or other subpopulations of ...

93. Noninvasive Monitoring and Control of Nasal Cannula Flow and Pressure
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices   |  Software/Algorithms
Inventor:  Chipman, Daniel W.; Dwyer, William J.; Strong, Kevin
Background:

Although nasal continuous positive airway pressure (CPAP) is typically administered for a range of ...

94. Treatment of Airway Hyperactivity Disorders with Antagonists of iNKT Cell Activation Presented by CD1d
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Methods
Inventor:  Akbari, Omid; Wilson, S. Brian
Background:

According with the National Institute of Health, more than 20 million people in the United States e ...

95. Simultaneous Fluorescence Lifetime, Emission, Excitation Spectroscopy (SFLEE)
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Imaging   |  Drug Discovery Tools   |  Medical Imaging
Inventor:  Bouma, Brett E.; Peng, LeiLei; Tearney, Guillermo J.
MGH Case Nos: 2308, 3398, 3604

Background:

The ability to simultaneously visualize fluorescent markers ...

96. Polynucleotide and polypeptide Fat Metabolism Regulators and Uses Thereof
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Diagnostics/Biomarkers
Inventor:  Ashrafi, Kaveh; Ruvkun, Gary B.
Background:
In the United States there are more than 60 million obese individuals. Obesity increases the risks of d ...

97. Treatment for Compartment Syndrome
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices   |  Diagnostics/Biomarkers
Inventor:  Anderson, Richard Rox; Parrish, John A.; Vosburgh, Kirby
Background:

Compartment syndrome is a result of trauma that may occur in any soft tissue. Following trauma, th ...

98. Laser Illuminator
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices
Inventor:  Anderson, Richard Rox; Bhatta, Nayantara; Prahl, Scott
Background:

The invention relates to laser illuminators used primarily in medical applications. Lasers can be u ...

99. Image-Derived 18-F FDG Input Function for Assessment of Glucose Metabolism with PET
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Diagnostics/Biomarkers
Inventor:  Harris, Robert Scott; Musch, Guido; Schroeder, Tobias; Venegas, Jose G.; Vidal-Melo, Marcos F.; Winkler, Tilo
Background: Positron-emission tomography (PET) imaging of 18F-FDG is increasingly used to assess metabolic activity of ...

100. Imaging System for Obtaining Quantitative Perfusion Indices
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Imaging   |  Diagnostics/Biomarkers
Inventor:  Schwamm, Lee H; Sorensen, Alma Gregory
Background:

Measuring blood flow within the body can be a useful tool in diagnosing and treating patients. Per ...

101. Magnetic Ink Tattoos
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices
Inventor:  Anderson, Richard Rox; Khan, Misbah Huzaira
Background:

Approximately one in five young adults in the United States has been injected with tattoo inks by p ...

102. Adjuvant Photodynamic Therapy as a Radiation Sensitizer
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Methods
Inventor:  Hasan, Tayyaba; O'Hara, Julia A.; Pogue, Brian W.; Swartz, Harold M.
Background:

Tumors can have large regions where oxygen is scarce. Radiation therapy is known to be less effecti ...

103. Use of a Baculovirus to Express An Exogenous Gene in a Mammalian Cell
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Research Tools   |  Drug Discovery Tools
Inventor:  Boyce, Frederick M.
Background:

Currently, different methods allow expression of an exogenous gene in a mammalian cell. Among these ...

104. Treatment of Lymphoid Leukemias by Conteracting Rho H Gene Repression
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Methods   |  Therapeutics - Drugs
Inventor:  Shelley, Carl Simon; Zouitina-Galiegue, Sylvie
Background and Significance:
In the US, chronic lymphoid leukemias of white blood lymphocytes are the most common fo ...

105. Glucagon-like peptide-1 (GLP-1) stimulates cutaneous folliculogenesis
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Methods   |  Therapeutics - Drugs
Inventor:  Habener, Joel F.; List, James F; Mojsov, Svetlana
Background:

Dermatologists recognize many different types of hair loss, the most common by far being alopecia w ...

106. Tissue Engineering of Functional Blood Vessels
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Methods
Inventor:  Fukumura, Dai; Jain, Rakesh K.
Abstract:

In general, this invention provides methods and compositions for stabilizing, repairing, or replacing ...

107. ranscription Factor ZPB-89 Controls Generation of Hematopoietic Lineage in Zebrafish and Mouse Embryonic Stem Cells
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Methods   |  Therapeutics - Drugs   |  Therapeutics - Methods
Inventor:  Arnaout, Amin M
Background:
Hematopoietic development is closely linked to that of blood vessels and the two processes are regula ...

108. Automated Method and System for the Detection of Pulmonary Nodules on Medical Co
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Imaging
Inventor:  Betke, Margrit; Ko, Jane P.
Background

Each year a relatively large number of new cancer cases are diagnosed. Every one in four deaths in t ...

109. Improved Devices and Methods for Percutaneous Mitral Valve Repair
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices
Inventor:  Levine, Robert Aaron
THE INVENTOR
Robert A. Levine, MD, Professor of Medicine, MGH and Harvard Medical School

BACKGROUND
Mit ...

110. Rapid and Objective Determination of Pain
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Research Tools   |  Drug Discovery Tools   |  Research Tools
Inventor:  Becerra, Lino; Boas, David A.; Borsook, David
BACKGROUND
The invention relates to the field of determination of central nervous system (CNS) activity, for example ...

111. Enzyme-Responsive Substrates and MR Imaging of Enzymatic Activity
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Diagnostics/Biomarkers   |  Medical Imaging
Inventor:  Bogdanov, Alexei; Weissleder, Ralph
The Technology:

The invention features methods of detecting enzymatic activity (e.g., in a magnetic resonance i ...

112. Optically Orienting An Invasive Medical Device
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices
Inventor:  Patti, Jay Waldron
This new device includes a light source that displays a pattern of light that defines a coordinate system and is coupled ...

113. Culturing Liver Cells
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Drug Discovery Tools   |  Research Tools   |  Research Tools
Inventor:  Dunn, James; Tompkins, Ronald G; Yarmush, Martin L.
Background:

A combination of biological and non-biological approaches to replacing the detoxification function ...

114. Photochemical Tissue Bonding - A Novel Method of Tissue Repair
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Methods
Inventor:  Azar, Dimitri T.; Chan, Barbara P.; Johnson, Timothy Shane; Kochevar, Irene E.; Randolph, Mark A.; Redmond, Robert W.; Winograd, Jonathan
Invention Summary: Tissue repair through use of photochemical tissue bonding.

Background:

Major unmet ...

115. Ant-Hypertrophic Effects and Inotropic Effects of PICOT (PKC-Interacting Cousin of Thioredoxin)
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Methods
Inventor:  Hajjar, Roger J; Park, Woojin
Background:

The myocardium undergoes adaptive hypertrophic growth to augment cardiac output. While this respon ...

116. Diffusion MRI Using Spherical Shell Sampling
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Software/Algorithms   |  Medical Imaging
Inventor:  Tuch, David S.; Wedeen, Van J.
Background:

In the past decade, magnetic resonance imaging (MRI) methods have been developed that by mapping th ...

117. Transgenic Model of Heart Failure
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Research Tools   |  Drug Discovery Tools
Inventor:  Homey, Charles C; Ishikawa, Yoshihiro; Vantner, Stephen F.; Wagner, Thomas
The present invention relates to transgenic models of heart failure and, more particularly, to transgenic animals and me ...

118. Polynucleotides and Polypeptides for Molting and Uses Thereof
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Methods
Inventor:  Frand, Alison; Ruvkun, Gary B.
Applications:

- Drugs to treat nematode infections
- Drug targets for the development of nematacides, insec ...

119. Photodynamic Therapy with Methylene Blue for Post-interventional Vascular Wound
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Methods
Inventor:  La Muraglia, Glenn Michael
Invention Summary: Methods for preventing, inhibiting or minimizing restenosis and intimal hyperplasia in a person who ...

120. Calcium to Enhance the Engraftment Potential of Hematopoietic Stem Cell Preparations
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Methods   |  Therapeutics - Drugs
Inventor:  Brown, Edward M.; Olszak, Ivona T.; Poznansky, Mark C.; Scadden, David T.
This invention relates to methods and compositions for modulating movement of eukaryotic cells with migratory capacity. ...

121. Immuno-Modulatory and Anti-Infective Compound Against Microbial Infections
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Methods
Inventor:  Deziel, Eric; Lepine, Francois; Rahme, Laurence G.
Background:

The opportunistic pathogen Pseudomonas aeruginosa is a major cause of debilitating bacterial infect ...

122. Real-time Rigid Body Motion Correction using Cloverleaf Navigators
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Imaging   |  Software/Algorithms
Inventor:  Dale, Anders M.; Van Der Kouwe, Andre J. W.
Background:

A substantial number of clinical and research MRI scans are lost due to patient motion during scann ...

123. P21 Protects Primitive Hematopoietic Stem Cells from HIV-Infection by Blocing Viral Inegration
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Methods   |  Therapeutics - Drugs
Inventor:  Crumpacker, Clyde; Engleman, Alan; Scadden, David T.; Vandegraaff, Nick; Zhang, Jie Lin
Title: " p21 protects primitive hematopoietic stem cells from HIV infection by blocking viral integration"(MGH2898).
...

124. Taxol Resistant Associated Gene
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Methods
Inventor:  Duan, Zhenfeng; Feller, Aynn; Seiden, Michael V.
U.S. Patent Number 6,362,321

Background:

Acquired drug resistance to currently available chemotherapeu ...

125. Method for Measuring NMR Projections Despite Significant Dead Time
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Imaging   |  Diagnostics/Biomarkers
Inventor:  Chesler, David A.
Background:

In nuclear magnetic resonance (NMR) spectroscopy sequence, the radio frequency pulse is typically u ...

126. Ultra Rapid Freezing for Cell Cryopreservation
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices
Inventor:  Fowler, Alex; Toner, Mehmet
Background:

Conventional cryopreservation protocols rely on the addition of cryoprotectants to control the form ...

127. A Novel Method for Determining the Efficacy of CTL's Based on the Immune Cell Mi
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Drug Discovery Tools   |  Therapeutics - Drugs   |  Research Tools
Inventor:  Brainard, Diana; Poznansky, Mark C.
Summary
Inhibiting an abnormal immune response, useful for treating e.g. autoimmune disease or allergy, comprises ad ...

128. Metabolic Profiling of Prostate Cancer with Tissue Magnetic Resonance Spectroscopy
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Imaging   |  Diagnostics/Biomarkers
Inventor:  Cheng, Leo Ling; Dai, Guangping; Halpern, Elkan; Jenkins, Bruce G.; Wu, Chin-Lee
BACKGROUND INFORMATION
Magnetic resonance spectroscopy (MRS) technologies can be used to detect the presence and con ...

129. A Novel Method for Rapid Site Specific Targeting in Mice
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Research Tools   |  Drug Discovery Tools
Inventor:  Seed, Brian S.; Yang, Yi
Background:

The traditional method for generating gene deletion or knockout mice is a time-consuming and labor- ...

130. Diagnosis of Wegener's Granulomatosis
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Diagnostics/Biomarkers
Inventor:  Arnaout, Amin M; McCluskey, Robert T.; Niles, John L.
Abstract:

A purified protein (p29) capable of binding autoantibodies present in the sera of individuals sufferi ...

131. A Phototherapy Method For Treatment of Acne
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Methods
Inventor:  Gillies, Robert; Kollias, Nikoforos; Tian, Wei Dong
Background:

The invention involves methods for the treatment and prevention of acne by exposing the subject's s ...

132. Multi-segment Cone-beam Reconstruction Algorithm for Tomosynthesis Imaging
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Imaging   |  Software/Algorithms
Inventor:  Kopans, Daniel Benjamin; Moore, Richard H.; Wu, Tao
Title: "Multi-Segment Cone-beam Reconstruction Algorithm for Tomosynthesis Imaging" (MGH2309)

Inventors: Dani ...

133. Device for Blood Vessel Perfusion, Occlusion and Filtration
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices
Inventor:  Titus, James S.; White, Jennifer K.
Abstract
A perfusion cannula constructed of a wire mesh or other structure having an expandable portion capable of e ...

134. Radiation-Delivery Device
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices   |  Medical Devices   |  Therapeutics - Drugs
Inventor:  Anderson, Richard Rox
Background:

Radiation sources, such as lasers, are used in a variety of medical applications including the remo ...

135. Molecular Controls Over Cortico Signal Motor Neuron Survival and Differentiation
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Drug Discovery Tools   |  Research Tools
Inventor:  Arlotta, Paola; Macklis, Jeffrey; Molyneaux, Bradley J.
The invention relates to methods for isolating and purifying specific types of neurons, such as cortical or other projec ...

136. Substrate for Detecting Myeloperoxidase Activity Using Magnetic Resonance Imagin
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Research Tools   |  Drug Discovery Tools   |  Medical Imaging
Inventor:  Bogdanov, Alexei; Chen, John; Querol, Manuel; Weissleder, Ralph
Background
It is widely anticipated that magnetic resonance imaging (MRI) would benefit from the use of "MR-responsi ...

137. Composition and Method for Enhancing Fibrinolysis
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Methods   |  Therapeutics - Drugs
Inventor:  Bajorath, Jurgen; Harris, Linda; Hsu, Mei Yin; Matsueda, Gary R; Novotny, Jiri; Reed, Guy L.
The present invention relates to a novel alpha-2-antiplasmin-binding molecules and treatment for pulmonary embolism, myo ...

138. APPARATUS AND METHOD FOR ASCERTAINING AND RECORDING ELECTROPHYSIOLOGICAL SIGNALS
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices   |  Drug Discovery Tools   |  Medical Devices
Inventor:  Belliveau, John W.; Bonmassar, Giorgio
Many laboratories worldwide are interested in recording electrophysiological signals during MRI/fMRI in human subjects o ...

139. Photosensitizer Conjugates for Pathogen Targeting
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Methods
Inventor:  Hamblin, Michael R.; Hasan, Tayyaba; Soukos, Nikolaos S.
SUMMARY: The invention covers conjugate molecules, which include photosensitizer compositions conjugated to non-antibody ...

140. Mannose-Binding Lectin Null Mice as a Vehicle for Enhanced Antibody Response
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Drug Discovery Tools   |  Research Tools
Inventor:  Ezekowitz, R. Alan; Jensenius, Jens Chr.; Shi, Lei; Takahashi, Kazue
Background:

The mannose-binding lectin (MBL) is a serum molecule that plays a role in first line host defense. ...

141. Complement-Resistant Baculoviruses
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Research Tools   |  Drug Discovery Tools
Inventor:  Barsoum, James G; Boyce, Frederick M.
Background:

Currently, different methods allow expression of an exogenous gene in a mammalian cell. Among these ...

142. Method for Parallel Image Reconstruction Using Automatic Regularization
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Imaging
Inventor:  Lin, Fa-Hsuan
BACKGROUND OF THE INVENTION

In dynamic MRI applications, such as functional imaging, interventional imaging an ...

143. Method for Treating Cardiac Malfunction
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Drugs   |  Therapeutics - Methods
Inventor:  Hallaq, Haifa A.; Haupert, Garner Tripp
BACKGROUND OF THE INVENTION

Digitalis, digoxin, ouabain and related substances are cardiac glycosides deriv ...

144. Devices and Methods for Improved Cell Manipulation in Microfluidic Devices
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Research Tools   |  Drug Discovery Tools   |  Medical Devices
Inventor:  Irimia, Daniel; Toner, Mehmet
Background:

Lab-on-a-chip technologies for cell-based, basic research or clinical diagnostic applications pro ...

145. Method for Inhibition of Nicotine or Cocaine Craving
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Drugs   |  Therapeutics - Methods
Inventor:  Breiter, Hans C.; Rosen, Bruce R.
Background:

The repeated use of psychostimulants such as nicotine, cocaine and amphetamine leads to a profound ...

146. Compact Epstein - Barr Virus Replicons
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Research Tools   |  Drug Discovery Tools
Inventor:  Seed, Brian S.
Background:

The cis-acting origin of replication (OriP) and the Epstein-Barr (EBV) nuclear antigen 1 (EBNA1) ar ...

147. Use of the RTX Secretion System to Achieve Heterologous Antigen Secretion in Vib
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Vaccines   |  Research Tools   |  Vaccines
Inventor:  Bikowski, Margaret; Pei, Lei; Ryan, Edward T.
Title: Use of the RTX secretion system to achieve heterologous polypeptide secretion by Vibrio cholerae (MGH 2522)
...

148. Bioprosthetic Control Algorithm
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices   |  Software/Algorithms
Inventor:  Brown, Emery Neal; Eden, Uri Tzvi; Srinivasan, Lakshminarayan; Willsky, Alan S.
Inventors: Lakshminarayan Srinivasan and Alan Willsky (MIT) / Uri Eden, and Emery Brown (MGH)

Applications:
149. SOK-1 and Methods of Uses
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Research Tools   |  Drug Discovery Tools
Inventor:  BonVentre, Joseph Vincent; Force, Thomas L.; Kyriakis, John M.; Pombo, Celia
A SOK polypeptide, an isolated DNA having a nucleotide sequence encoding a SOK polypeptide, and a method of determining ...

150. Method and Apparatus for Reducing the Appearance of Skin Markings Utilizing Electromagnetic Radiation
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices
Inventor:  Anderson, Richard Rox; Khan, Misbah Huzaira
Background:

There has been an increasing demand for repair of or improvement to skin defects or marks, which ca ...

151. Magnetic Resonance Reverse Imaging
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Imaging   |  Software/Algorithms
Inventor:  Lin, Fa-Hsuan
Background:
A major problem in Magnetic Resonance Imaging (MRI) is its susceptibility to artifacts caused by inter ...

152. Devices and Methods for Detecting Cells and Other Analytes from Solutions
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices   |  Diagnostics/Biomarkers
Inventor:  Cheng, Xuanhong; Demirci, Utkan; Irimia, Daniel; Rodriguez, William; Toner, Mehmet
Background:

Of the 40.4 million people infected with HIV globally, more than 35 million live in developing coun ...

153. Gene Transfer of C. Elegans N-3 Fatty Acid Desaturase Optimizes Fatty Acid Compo
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Methods
Inventor:  Kang, Jing X
"Compositions and Methods for Modifying the Content of Polyunsaturated Fatty Acids"
Inventor: Kang, Jing X.

...

154. Magnification Breast Tomography System and Method
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Imaging   |  Diagnostics/Biomarkers
Inventor:  Kopans, Daniel Benjamin; Moore, Richard H.
Title: "Imaging System and Related Techniques" (MGH 2561)

Inventors: Daniel Kopans, M.D. & Rick Moore, Ph.D. ...

155. Improved Methods to Preserve Biomaterials with Non-metabolizable Sugars
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Methods   |  Research Tools   |  Therapeutics - Drugs   |  Drug Discovery Tools
Inventor:  Elliott, Gloria; Sugimachi, Keishi; Toner, Mehmet
Background:

As advances are made in tissue engineering, transplantation, reproductive medicine, and stem cell ...

156. The genes controlled by the Pseudomonas aeruginosa transcription factor MvfR inc
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Drug Discovery Tools   |  Therapeutics - Drugs   |  Research Tools   |  Therapeutics - Drugs
Inventor:  Deziel, Eric; Gopalan, Suresh; Lepine, Francois; Mindrinos, Michael N.; Rahme, Laurence G.; Tompkins, Ronald G; Xiao, Gaoping
Background:

The opportunistic pathogenic bacteria Pseudomonas aeruginosa is a major cause of debilitating infec ...

157. Antibodies that Bind to a2-Antiplasmin Crosslinked to Fibrin Which Do Not Inhibit Plasma a2-Antiplasmin
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Methods   |  Therapeutics - Drugs
Inventor:  Bode, Cristoph; Haber, Edgar; Matsueda, Gary R; Reed, Guy L.
Abstract:

The present invention relates to a treatment for myocardial infarction and blood clots within a patie ...

158. Photodynamic destruction of bacterial spores
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Methods
Inventor:  Demidova, Tatiana; Hamblin, Michael R.
SUMMARY
Background:

Spore formation is a mechanism by which some Gram positive bacteria (e.g. B. anthracis ...

159. COMPOUNDS FOR MODULATING INTEGRIN CD11b/CD18
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Methods
Inventor:  Arnaout, Amin M; Gupta, Vineet
Summary:

Integrins are heterodimeric receptors that mediate cell adhesion, migration and signaling and play rol ...

160. Transgenic Plants Expressing a dual Specificity MAPK Phosphatase and Uses Thereof
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Research Tools   |  Drug Discovery Tools
Inventor:  Chiu, Wan-Ling; Sheen, Jenq-Yunn
Background:

Increasing crop yield is limited by available arable land and restricted growing seasons in many lo ...

161. Delay-Compensated Calculation of Cerebral Blood Flow
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Imaging   |  Diagnostics/Biomarkers
Inventor:  Sorensen, Alma Gregory; Wu, Ona
Applications:

Software that may be manufactured and/or sold by MRI manufacturers, either as part of the origina ...

162. Lensless Differential Mi croscopy for High Resolution Imaging
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Imaging
Inventor:  Bilenca, Alberto; Bouma, Brett E.; Ozcan, Aydogan; Tearney, Guillermo J.
Background:

This new imaging modality achieves high spatial resolution without the use of a lens. In this appr ...

163. A laryngoscopic instrument for the measurement of the mechanical properties of vocal tissues.
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices
Inventor:  Ottensmeyer, Mark
Case Manager: Steven Wernicki, JD

Title: A Laryngoscopic Instrument for the Measurement of the Mech ...

164. Novel Geometry for Construction of Phased Array MRI Coils on Curved Surfaces
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices   |  Medical Imaging
Inventor:  Wald, Lawrence L; Wiggins, Graham Charles
This invention is based, in part, on the recognition that new patterns of coil elements can be arranged on surfaces havi ...

165. Percutaneous Ventricular Stent/Partial Mital Annuloplasty
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices
Inventor:  Wood, Malissa J.
INVENTOR
Wood, Malissa

SUMMARY
Background:

Today the average American has a 20% chance of dev ...

166. Apparatus for Dissolution and Delivery of Gases
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Imaging   |  Medical Devices
Inventor:  Layfield, Dominick; Venegas, Jose G.
Title: "Apparatus for Dissolution and Delivery of Gases" (MGH 1356)

Inventors: Drs. Jose Venegas and Dominic ...

167. Compositions for the Inhibition of the BMP Signaling Pathway
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Methods   |  Therapeutics - Drugs
Inventor:  Bloch, Kenneth D.; Cuny, Gregory; Laha, Joydev; Peterson, Randall; Xing, Xuechao; Yu, Paul B.
Summary

A small molecule inhibitor of bone morphogenetic protein (BMP) signaling, that has potential as a pharm ...

168. TISSUE DISORDER IMAGING ANALYSIS
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Imaging   |  Software/Algorithms
Inventor:  Ay, Hakan; Menezes, Nina M; Sorensen, Alma Gregory
The invention is based, at least in part, on the discovery that if one uses imaging-based techniques to identify and ana ...

169. Targeting Brain Cells Via Eye Drops by SPION-gfap in Living Subjects
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Diagnostics/Biomarkers   |  Medical Imaging
Inventor:  Liu, Christina H.; Liu, Philip K.
Gliosis is a process involving the outgrowth of a fibrous network of glia in the region of brain damage. This outgrowth ...

170. Ouabain-Specific Monoclonal Antibodies
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Drugs   |  Therapeutics - Drugs
Inventor:  Haupert, Garner Tripp; Margolies, Michael N.; Parharmi-Seren, Behnaz
ABSTRACT

The invention relates to a monoclonal antibody or antigen binding fragment thereof having binding spec ...

171. Quantitative Bone Matrix Imaging by Solid State Proton Magnetic Resonance Imaging
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Diagnostics/Biomarkers   |  Diagnostics/Biomarkers
Inventor:  Ackerman, Jerome L.; Chesler, David A.; Glimcher, Melvin J.; Wu, Yaotang
Background:

It is estimated that 10 million Americans have osteoporosis and that 34 million more (or 55% of Ame ...

172. Endoscopic Ultrasound Brush Biopsy System: Sonobrush
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices
Inventor:  Brugge, William R
Background:

Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) has become a powerful technique in th ...

173. MEDICAL PROCEDURE TRAINING SYSTEM
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices
Inventor:  Chaumet, Yann; Cotin, Stephane; Dawson, Steven L.; Neumann, Paul Francis; Ottensmeyer, Mark
The present invention provides a surgical training system including a mannequin having anatomical characteristic derived ...

174. Accelerated Magnetization Recovery in MRI Pulse Sequences by Feedback Enhanced Radiation Dumping
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Imaging
Inventor:  Huang, Susan; Wald, Lawrence L; Witzel, Thomas
When a substance such as human tissue is subjected to a uniform magnetic field (polarizing field B0), the individual mag ...

175. Importance of FADD Signaling in Serum-deprivation-and Thypoxia-Induced Cardiomyo
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Methods
Inventor:  Chao, Wei; Rosenzweig, Anthony; Shen, Yan
METHODS FOR TREATING, PREVENTING, OR REDUCING CARDIAC DISORDERS USING FADD INHIBITORS (MGH case2147)

BACKGROUND ...

176. Tissue engineered compositions and uses thereof for the treatment of aneurysms
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices
Inventor:  Hoh, Brian L.; Ogilvy, Christopher S.; Pryor, Johnny C.; Vacanti, Joseph P.
Background:

An aneurysm is an abnormal bulging outward of the arterial wall. Although they can occur in any pa ...

177. An Automated Phototherapeutic Psoriasis Treatment System
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices
Inventor:  Anderson, Richard Rox; Ivanov, Sergei; Webb, Robert H.
Background:

Psoriasis is a chronic disease characterized by sharply demarcated erythematous plaque with a silve ...

178. Immune Regulation for Tolerance in Organ Transplantation
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Methods
Inventor:  LeGuern, Christian A
Applications:

Control of cytotoxic T-cell to:
1. Induce tolerance to allografts or xenografts.
2. ...

179. Simultaneous Fluorescence Lifetime, Emission, Excitation Spectroscopy (SFLEE)
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Imaging
Inventor:  Bouma, Brett E.; Hasan, Tayyaba; Peng, LeiLei; Tearney, Guillermo J.; Verma, Sarika
MGH Case Nos: 2308, 3398, 3604

Background:

The ability to simultaneously visualize fluorescent markers ...

180. Cardiac Devices and Methods for Minimally Invasive Repair of Ischemic Mitral Reg
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices
Inventor:  Levine, Robert Aaron; Messas, Emmanuel
INVENTORS
Robert A. Levine, MD, Emmanuel Messas, MD

SUMMARY
Ischemic mitral regurgitation (MR) is a com ...

181. Electroencephalograph sensor for use with magnetic resonance imaging and methods using such arrangements
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices
Inventor:  Belliveau, John W.; Bonmassar, Giorgio; Ives, John W.
The present invention is directed to a signal recording system and a method for recording such signals (I, for recording ...

182. RobopsyTM - A Needle Biopsy Guidance System
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices   |  Medical Imaging
Inventor:  Barrett, Steven R.; Gupta, Rajiv; Hanumara, Nevan C.; Shepard, Jo-Anne; Slocum, Alexander H., Sr.; Walsh, Conor
Applications:

· Image-guided Needle Biopsy
· Brachytherapy

Background:

According ...

183. Rapid Immunoselection Cloning Method
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Methods   |  Drug Discovery Tools   |  Therapeutics - Methods
Inventor:  Allen, Janet; Amiot, Martine; Aruffo, Alejandro A; Camerini, David; Lauffer, Leander; Oquendo, Patricia; Seed, Brian S.; Simmons, David; Stamenkovic, Ivan; Stengelin, Siegfried
Abstract:

A simple and highly efficient method for cloning cDNAs from mammalian expression libraries based on t ...

184. Bed Level Indicator
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices
Inventor:  Williams, Samuel Zev
Many hospitalized patients must be confined to beds that need to be kept at specified angles in order to promote treatme ...

185. Therapeutic Use of Phosphodiesterase 5 Inhibitors (PDE5Is) for Muscular Dystrophies
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Methods
Inventor:  Asai, Akihito; Martyn, Jeevendra J; Yasuhara, Shingo
Background: Duchenne Muscular Dystophy (DMD) and Becker's Muscular Dystrophy (BMD) are progressive pediatric diseases ...

186. Targeting of Sebaceous Follices as Treatment for Sebaceous Gland Disorders
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Methods
Inventor:  Anderson, Richard Rox
Background:

Acne vulgaris affects approximately 17 million people in the United States and is the most common s ...

187. Compositions and Methods Relating to Target-Specific Photodynamic Therapy
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Methods
Inventor:  Hasan, Tayyaba
Background:

Photodynamic therapy (PDT) is an emerging modality in use for cancer and non-cancer therapeutics. P ...

188. In Vivo Flow Cytometry
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Imaging   |  Diagnostics/Biomarkers
Inventor:  Lin, Charles P.; Sipkins, Dorothy; Wei, Xunbin
Background:

Current methods for detecting and quantifying various types of cells circulating within a subject's ...

189. Perfusion Weighted MRI with Local Arterial Input Function
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Software/Algorithms   |  Medical Imaging
Inventor:  Benner, Thomas; Lorenz, Cory; Sorensen, Alma Gregory
Perfusion-weighted magnetic resonance imaging is a common imaging technique used in the clinical treatment of patients w ...

190. Ovarian cancer side population defines cells with stem cell-like characteristics and Mullerian Inhibiting Substance responsiveness
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Methods
Inventor:  Dombkowski, David; Donahoe, Patricia K.; Maclaughlin, David T.; Pieretti, Rafael V.; Preffer, Frederic I.; Szotek, Paul P.
The identification of "side population" (SP) cells in a number of unrelated human cancers has supported the idea that ca ...

191. Cell Culture Systems and Methods for Organ Assist Devices
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices
Inventor:  Balis, Ulysses J; Cosman, Maury D.; Dimilla, Paul A.; Tilles, Arno A.; Toner, Mehmet; Yarmush, Martin L.
Background:

Nearly 50,000 Americans die each year from liver disease. When liver disease progresses to liver f ...

192. Methods for Improved Cell Preservation using Desiccation
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Drug Discovery Tools   |  Research Tools   |  Drug Discovery Tools
Inventor:  Acker, Jason; Baust, John M; Bhowmick, Sankha; Chen, Tani; Fowler, Alex; Toner, Mehmet
Background:

A critical need exists in biotechnology and clinical care for the long-term storage of mammalian ce ...

193. Female Germline Stem Cell-based Technologies for Regulating Fertility and Ovaria
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Methods   |  Therapeutics - Methods   |  Therapeutics - Methods
Inventor:  Johnson, Joshua; Tilly, Jonathan L.
Cell, Volume 122 Issue 2: July 28, 2005
Johnson et al.
Oocyte Generation in Adult Mammalian Ovaries by Putativ ...

194. Cosmetics Based on Skin Optics
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices
Inventor:  Anderson, Richard Rox
Background:

Most existing cosmetics are in the form of a cream or powder that creates an opaque layer to hide w ...

195. Nanoparticle enzyme substrates
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Imaging   |  Medical Imaging   |  Research Tools
Inventor:  Josephson, Lee; Perez, Jesus Manuel; Weissleder, Ralph; Zhao, Ming
Background: Non-invasive imaging of molecular expression in vivo with high resolution and high sensitivity would be a ...

196. Telescoping Multisite Pacing Left Ventriclar Lead
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices
Inventor:  Heist, Kevin E.; Singh, Jagmeet
Technical description of the invention
Left ventricular pacing lead, which enables pacing of the heart from two sep ...

197. TCR Alpha and Beta Chain Sequence of HIV-1 and HCV-Specific CD8+ T Cell Clones
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Diagnostics/Biomarkers   |  Therapeutics - Drugs   |  Diagnostics/Biomarkers
Inventor:  Altfeld, Marcus; Lauer, Georg; Lichterfeld, Mathias; Walker, Bruce D.; Yu, Xu
Inventors: Bruce Walker et al., Infectious Disease (PARC)

Background:

The human T-cell receptor (TCR) ...

198. Methods of Screening for Compounds which Inhibit the Direct Binding of Ras to Raf and Biologic Compounds that Inhibit Ras-Raf Protein Interactions
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Research Tools   |  Drug Discovery Tools
Inventor:  Avruch, Joseph; Marshall, Mark S.; Zhang, Xian-Feng
Background:

Mutations in the ras gene have been associated with many different types of human cancers. Those m ...

199. A Method for Generating Stable Forms of High Affinity Integrin Domains
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Methods   |  Therapeutics - Drugs
Inventor:  Arnaout, Amin M; Li, Rui; Xiong, Jiang Ping
Field:
Novel high affinity integrin polypeptide useful in the treatment of restenosis and parasitic diseases.
...

200. Expression of an Exogenous Gene in A Mammalian Cell by use of a Non-Mammalian DNA Virus Having An Altered Coat Protein
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Research Tools   |  Drug Discovery Tools
Inventor:  Barsoum, James G; Boyce, Frederick M.
Background:

Currently, different methods allow expression of an exogenous gene in a mammalian cell. Among these ...

201. Apparatus and Method for Determining the Size of an Object During Endoscopy
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices   |  Diagnostics/Biomarkers
Inventor:  Nishioka, Norman S.
An endoscopic imaging system for viewing an object within a patient's body cavity includes: an endoscope for viewing an ...

202. High Level Expression of Proteins
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Vaccines   |  Drug Discovery Tools   |  Vaccines
Inventor:  Seed, Brian S.
Abstract:

The invention features a synthetic gene encoding a protein normally expressed in a mammalian cell wh ...

203. Anti-Viral Compounds, Compositions and Methods
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Research Tools   |  Therapeutics - Methods   |  Drug Discovery Tools
Inventor:  Beeler, Aaron B.; Chung, Raymond; Kim, Sun Suk; Matchacheep, Sirinya; Peng, Lee F.; Porco Jr., John A.; Sakamoto, Naoya; Schreiber, Stuart L.
Background:

Hepatitis C Virus (HCV) infects over 170 million people worldwide and frequently leads to cirrhosis ...

204. Improved Chest Tube Catheter to Prevent Pneumothorax and Fluid Contamination
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices
Inventor:  Gaissert, Henning
Background:

Negative air pressure in the pleural space is needed to maintain a lung in its expanded state. Che ...

205. Biosynthesis of HIF
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Methods
Inventor:  Gullans, Steven Rolf; Haupert, Garner Tripp
Abstract:

The present invention relates to a method of identifying an agent (e.g., petide, small molecule) that ...

206. Purposeful Movement of Human Migratory Cells Away from an Agent Source
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Methods
Inventor:  Papeta, Natalia; Potts, John T.; Poznansky, Mark C.; Vianello, Fabrizio
Background:

Cell migration in response to specific stimuli plays an important role in physiological and patholo ...

207. Salmonella Secreted Proteins and Uses Thereof
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Vaccines
Inventor:  Miller III, Samuel I.
Substantially pure Salmonella secreted proteins (Ssp), the secretion of which is dependent upon the expression of PrgH; ...

208. Simultaneous Fluorescence Lifetime, Emission, Excitation Spectroscopy (SFLEE)
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Imaging   |  Diagnostics/Biomarkers
Inventor:  Bouma, Brett E.; Motz, Jason; Tearney, Guillermo J.
MGH Case Nos: 2308, 3398, 3604

Background:

The ability to simultaneously visualize fluorescent markers ...

209. Antimicrobial Photoinactivation Using Chalcogen Analogs of Benzo[a]Phenoxazinium Dyes
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Methods
Inventor:  Demidova, Tatiana; Foley, James W.; Hamblin, Michael R.
Background:

Photodynamic therapy (PDT) is a medical treatment that utilizes visible light to selectively inacti ...

210. Cardiac Mesenchymal Fibroblast as a Feeder System for Embryonic Stem Cell-Derived Cardiac Progenitors
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Research Tools   |  Drug Discovery Tools
Inventor:  Caron, Leslie; Chien, Kenneth; Moretti, Allesandra; Nakano, Atsushi
"Cardiac mesenchymal fibroblast as a feeder system for embryonic stem cell-derived cardiac progenitors" (MGH 3155)
< ...

211. Polybiotin for SiRNA Therapy and Related Diagnostic Methods
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Research Tools   |  Research Tools   |  Research Tools
Inventor:  Elmaleh, David R.; Weinstein, Earl; Zetter, Bruce R.
Background:

In a very short time frame, short interfering RNA (siRNA) molecules have become indispensable to th ...

212. Photodynamic Therapy with Fullerenes
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Methods
Inventor:  Gali, Hariprasad; Hamblin, Michael R.; Mroz, Pawel; Pawlek, Anna; Tegos, George P.; Wharton, Timothy
Background:

Photodynamic therapy (PDT) is an increasingly important treatment option for a variety of clinical ...

213. Methods to Potentiate Cancer Therapies
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Drug Delivery
Inventor:  Jain, Rakesh K.; Seed, Brian S.
Disclosed are methods for potentiating the anti-cancer properties of an anti-cancer therapy in a mammal by administering ...

214. Altering the X-Chromosome Inactivation Pathway to Control the Timing of Differentiation in Human Embryonic Stem Cells
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Drug Discovery Tools   |  Research Tools
Inventor:  Lee, Jeannie T
Background:

The difficulty of maintaining human embryonic stem cells ("HESC") in the undifferentiated and pluri ...

215. Quantification of Cancer Progression Rates with Ornithine Decarboxylase mRNA
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Diagnostics/Biomarkers
Inventor:  Cheng, Leo Ling; Pohl, Ute; Wu, Chin-Lee
SUMMARY:
The invention covers the use of ornithine decarboxylase (ODC), and specifically ODC mRNA level measurement ...

216. Alkyl piperidine/piperazine compounds for diagnosis and treatment of CNS disorders
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Methods   |  Diagnostics/Biomarkers   |  Therapeutics - Drugs
Inventor:  Choi, Sung-Woon; Elmaleh, David R.; Fischman, Alan; Shoup, Timothy M.
Background:

Dopamingergic neurotransmitter systems are associated with a number of CNS disorders including coca ...

217. Artificial Enzymes Having Ligase Activity
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Research Tools   |  Drug Discovery Tools
Inventor:  Cho, Glen S.; Keefe, Anthony; Seelig, Burckhard; Szostak, Jack W.
Background:

Given the potential importance of RNA in research methodologies, diagnostics and therapeutics, enzy ...

218. Diffusion Imaging of Tissues
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Software/Algorithms   |  Medical Imaging
Inventor:  Wedeen, Van J.
Background:

In the past decade, magnetic resonance imaging (MRI) methods have been developed that by mapping th ...

219. Method for evaluating novel, stroke treatments using a tissue risk map
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Imaging
Inventor:  Sorensen, Alma Gregory; Wu, Ona
The present invention provides a method for utilizing a risk map indicating the probability of tissue infarction to eval ...

220. Treatment Method for Ocular Melanosis
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Methods
Inventor:  Akita, Hirotaka; Anderson, Richard Rox
Background:

Ocular melanosis (OM) is variable hyperpigmentation of the sclera and is a manifestation of the mor ...

221. Methods for Diagnosis, Prediction and Treatment of Asthma and Other Inflammatory Conditions Based on Eotaxin Coding Sequence Polymorphism
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Diagnostics/Biomarkers
Inventor:  Drazen, Jeffrey M.; Lilly, Craig M.; Luster, Andrew D.
Field: The invention relates to diagnosis, prediction and treatment of asthma, rhinitis and other inflammatory condi ...

222. Etomidate Analogues with Improved Pharmacokinetic and Pharmacodynamic Properties
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Methods
Inventor:  Forman, Stuart A.; Husain, Syed Shaukat; Miller, Keith W.; Raines, Douglas E.
Background:
Each year, nearly 30 million general anesthetics are administered in the U.S. alone. At the concentra ...

223. Method for diagnosing neurological, neurodegenerative and psychiatric diseases by magnetic resonance imaging using contrast agents with high magnetic susceptibility and extended plasma half life
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Diagnostics/Biomarkers   |  Medical Imaging
Inventor:  Cavagna, Friedrich; Jenkins, Bruce G.; Mandeville, Joseph
In its most important aspect, the present invention is a method to detect, diagnose and stage neurological disorders by ...

224. Methods of Evaluating and Predicting the Effects and Applications of Drugs Using
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Methods   |  Therapeutics - Methods   |  Therapeutics - Methods
Inventor:  Cantiello, Horacio F.; Raychowdhury, Malay K .; Tabatadze, David; Zamecnik, Paul C.
We have evolved a technique that appears to achieve a trinucleotide insertion into tissue culture cells bearing a specif ...

225. Apparatus and Method for Demarcating Tumors
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Diagnostics/Biomarkers   |  Medical Devices
Inventor:  Fallon, Jerome D.; Fewkes, Jessica Lynn; Flotte, Thomas J.; Kollias, Nikoforos
U.S. Patent No. 6,317,624
Abstract: The invention features an apparatus and method for demarcating the margins of ...

226. Herpes Symplex Virus-1 Vector Targeting Amplicon System and Method of Using Same
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Research Tools   |  Drug Discovery Tools
Inventor:  Breakefield, Xandra O.; Spear, Matthew
Background:

The availability of a selective and efficient gene delivery system is essential to the success and ...

227. Immune Modulation with Carbohydrate-Antigen Conjugates
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Methods   |  Therapeutics - Drugs
Inventor:  Adams, Eddie; Hacohen, Nir; Seeberger, Peter
Background:

In mounting an immune response to an antigen, the antigen must be recognized, captured, and process ...

228. Neuroimaging and Genetic Analysis
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Diagnostics/Biomarkers
Inventor:  Breiter, Hans C.; Gasic, Gregory P.; Rosen, Bruce R.
Background:

The prevalence of mental illness in the United States is estimated to be about 44 million adults an ...

229. Mammalian 2- Hybrid System
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Research Tools   |  Drug Discovery Tools
Inventor:  Isselbacher, Kurt J.; Shioda, Toshihiro
Background:

One approach for elucidating protein-protein binding in cells is the yeast-based two-hybrid system. ...

230. Cationic Fullerenes as Antimicrobial Sensitizers
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Methods
Inventor:  Hamblin, Michael R.; Wharton, Timothy
Background:

Photodynamic therapy (PDT) is a medical treatment that utilizes visible light to selectively inacti ...

231. Compositions and Methods for Analyte Detection
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Research Tools   |  Drug Discovery Tools
Inventor:  Anderson, Richard Rox; Cote, Gerard; Pishko, Michael; Russell, Ryan; Sirkar, Kaushik
U.S. Patent No. 6,485,703
Abstract: Provided are a variety of chemically sensitive, stable (insoluble over a specif ...

232. Blood Flow Navigator for Electrode-Free Cardiac Gating in MR Brain Imaging
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Imaging   |  Software/Algorithms
Inventor:  Van Der Kouwe, Andre J. W.
BACKGROUND OF THE INVENTION

The field of the invention is magnetic resonance imaging (MRI) methods and systems ...

233. Preperation and Purification of Pegylated Immunoconjugates
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Methods
Inventor:  Hasan, Tayyaba; Savellano, Mark; Skobe, Mihaela
Background:

Photodynamic therapy (PDT) is an emerging treatment for neoplastic and non-neoplastic diseases. PD ...

234. Targeting Lumican Proteoglycan in the Diagnosis and Treatment of Atherosclerosis
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Diagnostics/Biomarkers
Inventor:  Stone, James Robert
Atherosclerosis is one of the leading causes of death in developed countries. The atheroscleritic lesions develop at sit ...

235. Rotating Adaptor for Temporary Pacemaker
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices
Inventor:  Abate, David T.; Fifer, Michael A.
Description of Device:
The device is intended to stabilize a temporary pacing electrode, yet allow the caregiver to ...

236. Visualization of High-Resolution Diffusion MRI by Maximum Coherence Projection (
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Software/Algorithms   |  Medical Imaging
Inventor:  Wedeen, Van J.
Background:

In the past decade, magnetic resonance imaging (MRI) methods have been developed that by mapping th ...

237. Adjustable periventricular ring/ring like device/method for control of ischemic
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices
Inventor:  Guerrero, Jose Luis; Handschumacher, Mark D; Levine, Robert Aaron; Nathan, Nadia; Rudski, Lawrence G
Adjustable Periventricular Ring Device and Method for Control of Ischemic Mitral Regurgitation and Congestive Heart Dise ...

238. SELECTIVE MR IMAGING OF SEGMENTED ANATOMY
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Imaging   |  Software/Algorithms
Inventor:  Fischl, Bruce R.; Van Der Kouwe, Andre J. W.; Wald, Lawrence L
The present invention relates generally to nuclear magnetic resonance imaging (MRI) and magnetic resonance spectroscopy ...

239. Topologically Activated Optical Probe for In Vitro Imaging of Farnesyl Protein Transferase
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Diagnostics/Biomarkers   |  Drug Discovery Tools   |  Diagnostics/Biomarkers
Inventor:  Moore, Anna V; Pham, Wellington
Background:

Ras proteins play important roles in cell signal transduction including the cell division cycle, pr ...

240. Variable-Impedance Electrode System, with Fixed Relative Lead Layout and Motion Sensors, for Eletrophysiological Recordings During MRI
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices   |  Medical Imaging
Inventor:  Bonmassar, Giorgio; Purdon, Patrick
Background:

Electroencephalograms (EEG's) and magnetic resonance imaging scans (MRI's and fMRI's) are among the ...

241. High Dose Folic Acid for Treatment or Prevention of Hypertension
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Methods
Inventor:  Tawakol, Ahmed A
Title: "High Dose Folic Acid for Treatment or Prevention of Hypertension" (MGH - 2790)

Inventors: Tawakol, ...

242. Fabrication of Vascularized Organs using Microfabricated Two-Dimensional Molds
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices
Inventor:  Barnard, Edward J .; Borenstein, Jeffrey T; Ishii, Osamu; Kaazempur-Mofrad, Mohammad Reza; King, Kevin; Krebs, Nicholas; Maemura, Tomoyuki; Marentis, Theodore; Ogilvie, Jennifer; Orrick, Brian; Pritchard, Eleanor M.; Sevy, Alexander; Shin, Young-Moon Mich
Background:
The number of people waiting to receive a lifesaving organ transplant in the United States has reached a ...

243. Methods for the Cryopreservation of Mammalian Cells
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Drug Discovery Tools   |  Therapeutics - Drugs   |  Research Tools
Inventor:  Edd, Jon; He, Xiaoming; Toner, Mehmet; Toth, Thomas L.
Background:

Effective long term storage of mammalian cells is critical to the successful application of such ce ...

244. Liposome Cocktail
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Drug Delivery
Inventor:  Brown, Edward B.; Campbell, Robert B.; Fukumura, Dai; Jain, Rakesh K.
The invention is based on the discovery that angiogenic vessels have heterogeneous surface charge and that cationic lipo ...

245. Dynamin Mutants for Drug-Screening Assays and Gene Therapy of Proteinuric Kidney Disease
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Methods
Inventor:  Reiser, Jochen; Sever, Sanja
SUMMARY
This invention provides a method for treating cathepsin or dynamin-mediated disorders characterized by prot ...

246. Suppression of Noise and Reconstruction of Dynamic Magnetic Resonance Imaging Time Series Using Spatial Filters
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Imaging   |  Diagnostics/Biomarkers
Inventor:  Lin, Fa-Hsuan
Magnetic Resonance Inverse Imaging (InI) is capable of extremely fast data acquisition due to minimal gradient used for ...

247. Real-time Stroke Detection
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices   |  Diagnostics/Biomarkers
Inventor:  Belliveau, John W.; Bonmassar, Giorgio
Abstract:

Stroke is the third leading killer in the United States. Each year there are over 700,000 strokes in ...

248. A Diagnostic Score/Algorithm for Predicting the Likelihood of Death in Dyspneic Patients
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Diagnostics/Biomarkers
Inventor:  Baggish, Aaron L.; Blatt, Jacob; Januzzi, James L.; Lloyd-Jones, Donald M.
"A Diagnostic Score/Algorithm for Predicting the Likelihood of Death in Dyspneic Patients" (MGH - 3024)

INVENT ...

249. Apelin as a marker for the predisposition to atrial fibrillation and congestive heart failure
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Diagnostics/Biomarkers
Inventor:  Ellinor, Patrick T; Low, Adrian F.; MacRae, Calum
More than 2 million Americans have atrial fibrillation, an arrhythmia that is often paroxysmal or asymptomatic. Atrial f ...

250. Imaging-Based Algorithm to Predict Tissue Outcome Following Stroke Using Spatial Information
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Imaging   |  Software/Algorithms
Inventor:  Menezes, Nina M; Sorensen, Alma Gregory
BACKGROUND OF THE INVENTION

The field of the invention is nuclear magnetic resonance imaging (MRI) methods and ...

251. A Small Molecule Which Preferentially Inhibits the BMP Signaling Pathway
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Methods   |  Drug Discovery Tools   |  Therapeutics - Methods   |  Research Tools
Inventor:  Bloch, Kenneth D.; Hong, Charles C; Peterson, Randall; Yu, Paul B.
SUMMARY

Background:

Signaling involving Transforming Growth Factor (TGF) superfamily of ligands is ce ...

252. Strain Typing of E. Coli O157:H7
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Research Tools   |  Research Tools   |  Research Tools
Inventor:  Ausubel, Frederick M.; Blattner, Frederick; Calderwood, Stephen B.; Evans, Peter S.; Kudva, Indira; Perna, Nicole T.
Background:

In order to effectively contain outbreaks (natural or man-made), it is imperative for epidemiologis ...

253. Receptors Containing Antibody Effector Functions
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Methods
Inventor:  Seed, Brian S.
Background:

This invention relates to a fusion protein that comprises an immunoglobulin of the IgM, IgG1 or IgG ...

254. Antigens of Enterohemorrhagic Enteropathogenic Escherichia Coli for Diagnostic
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Diagnostics/Biomarkers   |  Vaccines
Inventor:  Calderwood, Stephen B.; Handfield, Martin; John, Manohar; Kudva, Indira
Background:

The bacteria Escherichia coli 0157:H7 is a human pathogen that causes a range of gastrointestinal i ...

255. Methods and Apparatus for Cell Analysis
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Research Tools   |  Research Tools   |  Research Tools
Inventor:  Leopold, Peter E.; Palmer-Toy, Darryl E; Sarracino, David; Sgroi, Dennis C.
Background:

Due to recent advances in genomics, more attention is being paid to the protein products of genes a ...

256. Keane Pulmonary Vein Ablation Stent
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Devices
Inventor:  Keane, David
A system for treating atrial fibrillation includes a stent and a delivery catheter for carrying the stent to a treatment ...

257. Real-time Rigid Body Motion Correction using Cloverleaf Navigators (Continuation)
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Software/Algorithms
Inventor:  Dale, Anders M.; Van Der Kouwe, Andre J. W.
Background:

A substantial number of clinical and research MRI scans are lost due to patient motion during scann ...

258. A Quorum Sensing-Associated Virulence Gene of Pseudomonas Aeruginosa Encodes a L
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Research Tools   |  Therapeutics - Methods   |  Research Tools   |  Therapeutics - Methods
Inventor:  Cao, Hui; Deziel, Eric; Lepine, Francois; Rahme, Laurence G.; Tompkins, Ronald G
Background:

The opportunistic pathogenic bacteria Pseudomonas aeruginosa is a major cause of debilitating infec ...

259. Mulitecho Bandwidth Matched Sequences for Structural Magnetic Resonance Imaging and Tissue Segmentation
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Software/Algorithms   |  Medical Imaging
Inventor:  Fischl, Bruce R.; Van Der Kouwe, Andre J. W.
Background:

In multispectral brain morphometry studies using magnetic resonance imaging (MRI), exact alignment ...

260. Objective Pain Monitor
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Diagnostics/Biomarkers   |  Medical Devices
Inventor:  Chrostowski, Mark; Mao, Jianren; Sundram, Hariharan
Background: Historically, individual pain perception was viewed as mainly a subjective phenomenon that does not lend it ...

261. Gridlock Nucleic Acid Molecules, Polypeptides, and Diagnostic and Tharapeutic Me
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Drug Discovery Tools   |  Research Tools
Inventor:  Fishman, Mark C.; Zhong, Tao
The invention provides a novel gene, gridlock, and its encoded protein. gridlock plays a role in vascular development an ...

262. Modified Soluble TGF-Beta Type III Receptor Extracellular Domain Used to Human Fc
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Methods   |  Therapeutics - Drugs
Inventor:  Babitt, Jodie L.; Crowley, William F. Jr.; del Re, Elisabetta; Lin, Herbert Y; Schneyer, Alan
Background:

Transforming growth factors (beta) (TGF- beta) are multifunctional proteins that bind to high affin ...

263. METHODS FOR OBTAINING MRI FREQUENCY MAPS
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Imaging
Inventor:  Reese, Timothy G.; Wedeen, Van J.
The present invention relates to MRI methods. In some embodiments, the MRI methods include obtaining a set of MRI signa ...

264. Sp110, a Leukocyte-Specific, Retinoic Acid Inducible, Nuclear Body Component that Functions as a Transcriptional Coactivator
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Methods   |  Therapeutics - Drugs
Inventor:  Bloch, Donald B.; Bloch, Kenneth D.
Summary:

Cloning and characterization of a full length cDNA encoding Sp110 (speckled 110), a novel 110 kDa poly ...

265. Correction for Artifiacts Induced by B0 and B1 Field Inhomogeneities in pH-Sensitive Chemical Exchange Saturation Transfer (CEST) Imaging
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Medical Imaging   |  Software/Algorithms
Inventor:  Sorensen, Alma Gregory; Sun, Phillip Zhe
Chemical exchange saturation transfer (CEST) imaging provides an indirect detection mechanism that allows quantification ...

266. A Novel Pathway for Inducing Bone Growth
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Methods   |  Therapeutics - Drugs
Inventor:  Clemens, Thomas; Johnson, Randall S.; Schipani, Ernestina
Summary:
The present invention provides for methods of identifying a compound capable of increasing osteoblast cell ...

267. A System for Regulated DNA Rearrangement of Gene Therapy Vectors
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Research Tools   |  Drug Discovery Tools
Inventor:  Freeman, Mason W.; Kovtun, Alexander; Murakawa, Masahiro; Park, Eun-Chung; Seed, Brian S.; Wang, Xing Zhong
Background:

Gene therapy relies on the use of vector to efficiently deliver the trangene to target cells. Among ...

268. PTH Analogs for Renal Osteodystrophy
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Methods   |  Therapeutics - Drugs
Inventor:  Bringhurst, F. Richard; Divieti, Paola; Juppner, Harald W.
Background:

Parathyroid hormone (PTH) is the major physiologic regulator of blood calcium and phosphate, and it ...

269. Inhibition of Insulin-Induced Adiposis
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Methods
Inventor:  Alexander-Bridges, Maria; Zhao, Hui-Fen
Background:

Lipogenesis is the cardinal adaptive response to excess carbohydrate consumption whereby humans mou ...

270. Assay for Therapies that Inhibit Expresion of the Cystolic Cu/Zn Superoxide Dism
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Research Tools   |  Drug Discovery Tools
Inventor:  Broom, Wendy; Brown, Robert H.
Background:

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative condition involving the loss ...

271. Fluorescent Agents for Real Time Measurement of Organ Function
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Diagnostics/Biomarkers   |  Medical Imaging
Inventor:  Rabito, Carlos A.
SUMMARY

Technology: Dr. Carlos Rabito, an MGH investigator in the Department of Radiology, has developed a fl ...

272. A Non-Invasive Method to Detect Matrix Matelloprotease that are Associated with Vasculature Damage in Live Animals
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Research Tools   |  Drug Discovery Tools   |  Drug Discovery Tools
Inventor:  Liu, Christina H.; Liu, Philip K.
A number of different approaches to imaging cells have been investigated using either optical, e.g., using green fluores ...

273. Selective Activation of Immunotoxins Through Binary Targeting
IP Type:  Licensable Technology
Organization:  Massachusetts General Hospital
Tech Type:   Therapeutics - Drugs   |  Therapeutics - Methods
Inventor:  Seed, Brian S.; Wolfe, Jia Liu
Background:

Selective killing of particular cell types is desirable in a variety of clinical settings, includin ...














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